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Difference between revisions of "Active Freeze Dryers"
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[[File:Active_Freeze_Dryers.jpg|thumb|right|200px|Active Freeze Dryers]] | [[File:Active_Freeze_Dryers.jpg|thumb|right|200px|Active Freeze Dryers]] | ||
[[File:Freeze_Drying.jpg|thumb| | [[File:Freeze_Drying.jpg|thumb|right|200px|Freeze Drying]] | ||
The '''Active Freeze Dryers''' are mainly used for freeze dying process. The freeze dying process is widely used in recent times. | The '''Active Freeze Dryers''' are mainly used for freeze dying process. The freeze dying process is widely used in recent times. | ||
Freeze-drying or commonly known as Lyophilization is a gentle, but technically complex drying process during which moisture is extracted from the frozen goods under vacuum conditions. So, many liquid active pharmaceutical ingredients for the pharmaceutical industry are quickly deep-frozen at temperatures of -70 to -100°C. Then, the frozen material is dried in a vacuum chamber. The ice evaporates at under pressure without becoming liquid - it sublimates. The water vapor is then extracted at increased vacuum and higher temperatures. For some types, the encapsulation of the glass bottles containing the ingredient is carried out under clean room conditions. Of all types of drying, freeze-drying leads to the least product changes and losses of ingredients. The Freeze Dryers operate in 3 steps: freezing, main drying, final drying. As from the second step, a vacuum pump is connected to the drying chamber to initiate the sublimation. Here, extreme parameters are reached. The vacuum sensor must withstand 5 x 10-3 mbar. This means no external particles must enter into the drying chamber, as they would contaminate the product. | Freeze-drying or commonly known as Lyophilization is a gentle, but technically complex drying process during which moisture is extracted from the frozen goods under vacuum conditions. So, many liquid active pharmaceutical ingredients for the pharmaceutical industry are quickly deep-frozen at temperatures of -70 to -100°C. Then, the frozen material is dried in a vacuum chamber. The ice evaporates at under pressure without becoming liquid - it sublimates. The water vapor is then extracted at increased vacuum and higher temperatures. For some types, the encapsulation of the glass bottles containing the ingredient is carried out under clean room conditions. Of all types of drying, freeze-drying leads to the least product changes and losses of ingredients. The Freeze Dryers operate in 3 steps: freezing, main drying, final drying. As from the second step, a vacuum pump is connected to the drying chamber to initiate the sublimation. Here, extreme parameters are reached. The vacuum sensor must withstand 5 x 10-3 mbar. This means no external particles must enter into the drying chamber, as they would contaminate the product. | ||