Difference between revisions of "Liposome Extruders"

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Liposome Extruders (view source)

Revision as of 04:36, 7 July 2022

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=Key Principles=
=Common Types of Liposome Extruders=
The key component of a high pressure homogenizer includes a homogenization unit such as diamond interaction chamber, and a high pressure pump unit. There is a specially designed fixed geometry inside the diamond interaction chamber. Strokes of the piston in the high pressure pump unit drive the samples through the interaction chamber at supersonic speed. In the chamber, materials are subjected to mechanical forces such as high shearing, high-frequency oscillation, cavitation and convective impact, and corresponding thermal effects simultaneously.  
Liposome extruders can be classified into three categories: hand driven liposome extruders, jacketed liposome extruders, and online liposome extruders. Each category is based on its different power sources.


These mechanical and physiochemical effects can induce change in the physical, chemical, and particle structure of the materials. This results in uniform and smaller nanoparticle size, achieving a homogenization effect.
==Hand Driven Liposome Extruders==
The hand driven liposome extruders are capable of processing the sample volume from 0.25mL to 2.5mL, which is suitable for mini sample volume applications during the experimental phase. It is operated by simply pushing the plunger manually.
 
There are two types of hand driven extruders:
* extruders under ambient temperature
* extruders with jacketed option
 
The hand driven Nano Pore liposome extruders with cooling jacket are designed for those extrusion conditions to control the sample temperature.
[[File:Hand_Driven_Liposome_Extruders.png|thumb|250px|right|Hand Driven Liposome Extruders]]


The interaction chamber is the core of the high pressure homogenizer, and its unique geometric internal structure is the main factor determining the effectiveness of the homogenization process. The intensifier pump exerts the required pressure for materials to pass through the interaction chamber at high speed. The pressure’s strength and stability are important to ensure the production of high-quality nanomaterials.


=Applications=
=Applications=
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